Search results for " SUCCESSFUL AGING"
showing 5 items of 5 documents
Cytokine serum profile in a group of Sicilian Nonagenarians
2011
The aim of our study was to evaluate the possibility of using multiplex analysis of the cytokine profile as a marker for successful aging by comparing cytokine plasmatic levels of a group of Sicilian nonagenarians with those of young controls. We analyzed a panel of 17 cytokines, comprehensive of haematopoietic factors T helper 1 (Th1), Th2, inflammation regulatory cytokines, and chemokines. The assay was carried out using the Luminex system. Interleukin (IL)-6 levels (p = 0.01) were increased in nonagenarians, whereas no modifications of other proinflammatory cytokines and chemokines were observed. Interferon-gamma (IFN-gamma) and IL-2 levels are unmodified, suggesting a substantial mainte…
Activities of the elderly and their satisfaction with life
2015
Abstract Successful aging (Rowe & Kahn, 1997) is conditioned by aspiration to be active and by the ability to maintain social relations. Activity improves the emotional lives of seniors and is associated with a reduction of some symptoms of aging. Our study verifies if the number of activities (informal and solitary) is associated with quality of life and whether subjective age may be a mediator of this relationship. The 136 seniors above 60 were tested by our authorial scale of activity and the WHOQOL-BRIEF. The results showed that older persons’ higher quality of life levels are related not only to the number of activities undertaken, but also to the frequency that these activities ar…
Genetic signatures of centenarians: Implications for achieving successful aging
2019
The extraordinary rise in the old population in the Western world underscores the importance of studies on aging and longevity to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies. Centenarians have reached the extreme limits of the human life span. They are the best example of extreme longevity, representing selected individuals in which the appearance of major age-related diseases has been consistently delayed or avoided. There is growing evidence that the genetic component of longevity becomes higher with survival at the age of over 90 years. For centenaries, it reaches up to 33% for…
Psychometric properties of the Spanish version of the Temporal Satisfaction with Life Scale (TSLS): A study on elderly attending to university progra…
2015
Several measures have been developed for the operalization of well-being, standing out the Satisfaction With Life Scale (SWLS). To cope with some of its problems the Temporal Satisfaction with Life Scale (TSLS) was developed. The aim of this study is to present and validate the Spanish version of the TSLS, in a sample elderly attending to University programs. The sample was composed of 737 elderly. Together with the TSLS, an indicator of general life satisfaction and the SF-8 Health Scale were used. Analyses included the study of factorial validity, estimations of reliability and external validity. Results of the confirmatory factor analysis were adequate: χ2(87)=454.593 (p<.001), CFI=.9…
Curcumin, inflammation, ageing and age-related diseases
2010
Abstract A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy between April 7 and 8th 2009. Here the lecture by Sikora with some input from the chairpersons Scapagnini and Barbagallo is summarized. Ageing is manifested by the decreasing health status and increasing probability to acquire age-related disease such as cancer, Alzheimer's disease, atherosclerosis, metabolic disorders and others. They are likely caused by low grade inflammation driven by oxygen stress and manifested by the increased level of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, encoded by genes activated by the transcription factor NF-κB. It is believed th…